Government leaders at all levels work together to make Monticello a choice location for industry and business. Incentives are utilized to attract new industrial development to the greater Monticello area. White County Economic Development assists prospective business and industry interested in locating in the county and Monticello.

City of Monticello leaders work at the regional level with Indiana Economic Development Corporation and Lafayette-West Lafayette Economic Development Corporation to ensure that no new business leads are overlooked. Monticello has created "Economic Revitalization Areas" where relocating or expanding companies can have real estate and personal property taxes abated for up to 10 years. The Monticello Economic Development Commission (EDC) works with the Mayor and City Council on important economic development issues.

The local Monticello Chamber of Commerce provides support to small and large business owners and has been instrumental in revitalizing the Monticello Downtown area.

Several Indiana agencies and organizations provide business incentives and assistance. Purdue University offers a popular and free Technical Assistance Program to area businesses to address concerns or issues faced.

Monticello's quality of life and recreational opportunities makes it a premier target for new and expanding businesses.